7-Aminocephalosporanic acid

7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor[1][2].

Product Specifications

CAS Number

[957-68-6]

Product Name Alternative

7-ACA

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Antibiotic; Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/7-Aminocephalosporanic-acid.html

Purity

99.15

Solubility

H2O : 1.1 mg/mL (ultrasonic; adjust pH to 14 with NaOH)

Smiles

O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](N)C1=O)O

Molecular Formula

C10H12N2O5S

Molecular Weight

272.28

Precautions

H317, H334

References & Citations

[1]Ding JM, et al. Identification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis. J Bacteriol. 2015 Nov 2;198 (2) :311-20.|[2]Zhang W, et al. 7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis. Biochem Biophys Res Commun. 2022 Sep 24;622:184-191.