Hydrocortisone phosphate

Hydrocortisone phosphate (Hydrocortisone 21-phosphate) is a derivative of the glucocorticoid Hydrocortisone hemisuccinate (HY-B1402) that increases serum luteinizing hormone (LH) levels. Hydrocortisone phosphate increases the activity of magnesium-dependent polymerases in the nucleolus. Hydrocortisone phosphate also serves as a substrate for alkaline phosphatase to localize phosphatases that hydrolyze steroid phosphates, and the role of alkaline phosphatase has been validated in adult mouse tissues[1][2][3].

Product Specifications

CAS Number

[3863-59-0]

Product Name Alternative

Hydrocortisone 21-phosphate; Cortisol 21-phosphate

UNSPSC

12352211

Hazard Statement

H315-H319-H320

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hydrocortisone-phosphate.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](C(COP(O)(O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

Molecular Formula

C21H31O8P

Molecular Weight

442.44

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Botte V, et al. "The hydrocortisone 21-phosphate as substrate for alkaline phosphatase: Histochemical remarks." Histochemie 16.2 (1968) : 195-196.|[2]Jacob, et al. Munro. "Regulation of nucleolar RNA metabolism by hydrocortisone." European Journal of Biochemistry 7.4 (1969) : 449-453.|[3]Kowalski, et al. "Effects of subchronic implantation of hydrocortisone phosphate-releasing osmotic pumps on peripheral gonadotropin levels and estradiol feedback to gonadotropin secretion in the cynomolgus monkey." Neuroendocrinology 57.2 (1993) : 330-339.