Pramipexole (dihydrochloride)

Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) [1][2][3].

Product Specifications

CAS Number

[104632-25-9]

UNSPSC

12352005

Hazard Statement

H302, H336, H402

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pramipexole-dihydrochloride.html

Concentration

10mM

Purity

99.73

Solubility

DMSO : 175 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

NC(S1)=NC2=C1C[C@@H](NCCC)CC2.[H]Cl.[H]Cl

Molecular Formula

C10H19Cl2N3S

Molecular Weight

284.25

Precautions

H302, H336, H402

References & Citations

[1]Kvernmo, T., et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28 (8) : p. 1065-78.|[2]Takashi Okura, et al. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci. 2007 Apr 3;80 (17) :1564-71.|[3]Ginetta Collo, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018; 2018: 4196961.|[4]P M Carvey, et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna) . 1997;104 (2-3) :209-28.|[5]Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12 (8) : dmm033860.