Orphenadrine (hydrochloride)

Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[1][2].

Product Specifications

CAS Number

[341-69-5]

UNSPSC

12352005

Hazard Statement

H301

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Orphenadrine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.[H]Cl

Molecular Formula

C18H24ClNO

Molecular Weight

305.84

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Pubill D, et al. Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo. Br J Pharmacol. 2001 Feb;132 (3) :693-702. |[2]Kornhuber J, et al. Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102 (3) :237-46.