Thiostrepton

Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation[1].

Product Specifications

CAS Number

[1393-48-2]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial; YAP

Type

Peptides

Related Pathways

Anti-infection; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Thiostrepton.html

Purity

99.80

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC(C(NC([C@@H](NC([C@](N[C@](C=C1)([H])[C@]2([H])O)([H])[C@@H](C)CC)=O)C)=O)=C)=O)C)N[C@](C3=NC(C(N[C@@](C(N/C(C4=N[C@]5([H])CS4)=C\C)=O)([H])[C@H](O)C)=O)=CS3)(CCC(C6=NC(C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=CS6)=N7)[C@@]7([H])C8=CSC([C@@]([C@H](OC(C9=CC([C@@H](O)C)=C1C2=N9)=O)C)([H])NC(C%10=CSC([C@](NC5=O)([H])[C@](C)(O)[C@H](O)C)=N%10)=O)=N8

Molecular Formula

C72H85N19O18S5

Molecular Weight

1664.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Ajaybabu V Pobbati, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10 (8) :3622-3635.|[2]Xuan Zhang, et al. Targeting of mutant p53-induced FoxM1 with Thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. Oncotarget. 2014 Nov 30;5 (22) :11365-80.|[3]Aniruddha Sengupta, et al. The dual inhibitory effect of Thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma. Int J Oncol. 2013 Sep;43 (3) :803-12.