Acid Ceramidase-IN-1
Product Specifications
UNSPSC Description
Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice[1].
Target Antigen
Ceramidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/acid-ceramidase-in-1.html
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(N1C(OC2=CC(C3CCN(C)CC3)=CC=C12)=O)NCC(C)C
Molecular Weight
331.41
References & Citations
[1]Di Martino S, et al. Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors. J Med Chem. 2020;63(7):3634-3664.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141866/Acid-Ceramidase-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141866/Acid-Ceramidase-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2415225-30-6
Available Sizes
Curated Selection
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