Acid Ceramidase-IN-1

Acid Ceramidase-IN-1 is orally active and blood-brain barrier penetrant acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM) . Acid Ceramidase-IN-1 reduces AC activity, accumulates ceramide species (Cer (d18:0/16:0), Cer (d18:1/16:0) ), and decreases sphingosine levels. Acid Ceramidase-IN-1 can be used for the study of severe neurological lysosomal storage diseases (LSDs) such as Gaucher’s disease (GD) and Krabbe’s disease (KD) [1].

Product Specifications

CAS Number

[2415225-30-6]

UNSPSC

12352005

Target

Ceramidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/acid-ceramidase-in-1.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(N1C(OC2=CC(C3CCN(C)CC3)=CC=C12)=O)NCC(C)C

Molecular Formula

C18H25N3O3

Molecular Weight

331.41

References & Citations

[1]Di Martino S, et al. Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors. J Med Chem. 2020;63 (7) :3634-3664.