Hematoporphyrin (dihydrochloride)
Product Specifications
UNSPSC Description
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light[1][2][3].
Target Antigen
Apoptosis; Endogenous Metabolite
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Hematoporphyrin-dihydrochloride.html
Purity
95.0
Solubility
DMSO : 62.5 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4)/C(C)=C(C(O)C)C4=C\C5=N/C(C(C(O)C)=C5C)=C\C(N2)=C1C)=N/3.Cl[H].Cl[H]
Molecular Weight
671.61
References & Citations
[1]Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.|[2]Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296.|[3]Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;22(1):49-53.ACS Nano. 2023 Nov 21.|Cancer Adv. 2024;7:e24021.|Free Radic Biol Med. 2023 Jul 25;207:239-246.|Nanyang Technological University. 2024.|Pharmaceutics. 2023 Aug 3, 15(8), 2076.|Chem Eng J. 390 (2020) 124521.|Drug Deliv. 2022 Dec;29(1):3358-3369.|FEBS Lett. 2021 Jan;595(2):206-219.|Int J Mol Sci. 2022 Apr 11;23(8):4218.|J Biol Chem. 2022 Aug 26;102417.|Lasers Med Sci. 2020 Feb;35(1):71-78.|Nat Biomed Eng. 2022 Dec 22.|Nat Commun. 2022 Jun 16;13(1):3468.|PLoS One. 2019 Sep 25;14(9):e0222331.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0754A/Hematoporphyrin-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0754A/Hematoporphyrin-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
17696-69-4
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