Hematoporphyrin
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light[1][2][3].
Product Specifications
CAS Number
14459-29-1
Product Name Alternative
Hematoporphyrin IX
UNSPSC
12352005
Target
Apoptosis; Endogenous Metabolite
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Hematoporphyrin.html
Purity
98.0
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4)/C(C)=C(C(O)C)C4=C\C5=N/C(C(C(O)C)=C5C)=C\C(N2)=C1C)=N/3
Molecular Formula
C34H38N4O6
Molecular Weight
598.69
References & Citations
[1]Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.|[2]Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41 (4) :2288-2296.|[3]Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;22 (1) :49-53.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 1
Isoform
Human Endogenous Metabolite
Citation 01
Chem Eng J. 390 (2020) 124521.|Drug Deliv. 2022 Dec;29 (1) :3358-3369.|FEBS Lett. 2021 Jan;595 (2) :206-219.|Int J Mol Sci. 2022 Apr 11;23 (8) :4218.|J Biol Chem. 2022 Oct;298 (10) :102417.|Lasers Med Sci. 2020 Feb;35 (1) :71-78.|Nat Biomed Eng. 2023 Mar;7 (3) :298-312.|Nat Commun. 2022 Jun 16;13 (1) :3468.|PLoS One. 2019 Sep 25;14 (9) :e0222331.|ACS Nano. 2023 Dec 12;17 (23) :23535-23544.|Acta Biomater. 2025 Jan 24:193:231-241.|Cancer Adv. 2024;7:e24021.|Free Radic Biol Med. 2023 Oct:207:239-246.|Nanyang Technological University. 2024.|Pharmaceutics. 2023 Aug 3;15 (8) :2076.
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