What is the catalog number for Pazufloxacin?

The catalog number for Pazufloxacin is HY-B0724B.

What sizes are available for Pazufloxacin?

Pazufloxacin is available in the following size(s): 1 Each.

Is Pazufloxacin in stock?

Pazufloxacin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Pazufloxacin?

Pazufloxacin is manufactured by QuantiMol.

What is the estimated delivery time for Pazufloxacin?

Estimated delivery time for Pazufloxacin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Pazufloxacin?

The safety data sheet for Pazufloxacin is available here: http://file.medchemexpress.com/batch_PDF/HY-B0724B/.

Pazufloxacin

Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa) . Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia[1][2][3][4][5].

Product Specifications

CAS Number

127045-41-4

Product Name Alternative

T3761

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pazufloxacin.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C1=O)=CN2[C@@H](C)COC3=C(C4(N)CC4)C(F)=CC1=C23)O

Molecular Formula

C16H15FN2O4

Molecular Weight

318.30

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Fukuoka, Y., et al., In vitro and in vivo antibacterial activities of T-3761, a new quinolone derivative. Antimicrob Agents Chemother, 1993. 37 (3) : p. 384-92.|[2]Muratani, T., M. Inoue, and S. Mitsuhashi, In vitro activity of T-3761, a new fluoroquinolone. Antimicrob Agents Chemother, 1992. 36 (10) : p. 2293-303.|[3]Takei M, et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob Agents Chemother. 2001 Dec;45 (12) :3544-7. |[4]Sousa J, et al. First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin, moxifloxacin and trovafloxacin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 1;930:104-11.|[5]Morinaga Y, et al. In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia. Exp Lung Res. 2010 Oct;36 (8) :484-90.