CARD9 Recombinant Rabbit Monoclonal Antibody [PSH0-41]
Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded by the CARD9 gene. It mediates signals from pattern recognition receptors to activate pro-inflammatory and anti-inflammatory cytokines, regulating inflammation. Homozygous mutations in CARD9 are associated with defective innate immunity against yeasts, like Candida and dermatophytes. CARD9 is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). This protein was identified by its selective association with the CARD domain of BCL10, a positive regulator and NF-κB activation. It is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-κB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
CARD9
Swiss Prot
Q9H257 Human, A2AIV8 Mouse, A2AIV8 Rat
Cellular Locus
Cytoplasm..
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within human CARD9 aa 1-200 / 536.
Isotype
IgG
Clone
PSH0-41
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
HL-60 cell lysate, THP-1 cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, THP-1, PC-3.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:100 ;FC: 1:500-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 62.2 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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