Niclosamide (monohydrate)
Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].
Product Specifications
CAS Number
73360-56-2
Product Name Alternative
BAY2353 monohydrate
UNSPSC
12352005
Hazard Statement
H410
Target
Antibiotic; Parasite; STAT
Type
Reference compound
Related Pathways
Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Niclosamide-monohydrate.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O.O
Molecular Formula
C13H10Cl2N2O5
Molecular Weight
345.13
Precautions
P273-P391-P501
References & Citations
[1]P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19 (2) :245-95.|[2]Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89-96.|[3]Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 15;22 (14) :3458-66.|[4]Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1 (9) :454-9.|[5]Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48 (7) :2693-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
STAT3
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