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Sodium butyrate

Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity[1][2][3][4][5].

Product Specifications

CAS Number

156-54-7

Product Name Alternative

Butanoic acid (sodium) ; Butyric acid (sodium)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Autophagy; Endogenous Metabolite; HDAC

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.67

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CCCC(O[Na])=O

Molecular Formula

C4H7NaO2

Molecular Weight

110.09

Precautions

H315, H319, H335

References & Citations

[1]Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13 (2) :921-929|[2]Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14 (1) :34|[3]Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27|[4]Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32 (4) :224-230|[5]Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Badge

Hot

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

HDAC; Human Endogenous Metabolite; Microbial Metabolite

Citation 01

Adv Sci (Weinh) . 2025 Oct 13:e09383.|Arch Insect Biochem Physiol. 2021 Jul;107 (3) :e21823.|Bioeng Transl Med. 2021 Apr 2;6 (3) :e10219.|bioRxiv. 2024 August 18.|BMC Vet Res. 2019 Jul 29;15 (1) :267. |Cell Death Dis. 2021 May 18;12 (6) :501.|Gut Microbes. 2023 Dec;15 (2) :2249143.|Int J Biol Macromol. 2026 Jan;335 (Pt 2) :149182.|Int J Stem Cell Res Ther. 2020, 7:068.|J Exp Clin Cancer Res. 2022 Jan 3;41 (1) :1.|J Neuroinflammation. 2021 Nov 4;18 (1) :254.|Nat Commun. 2025 Oct 10;16 (1) :9015.|Neurobiol Dis. 2018 Mar:111:12-25.|Patent. US20180263995A1.|Research Square Preprint. 2021 Sep.|Research Square Print. September 20th, 2022.|Sci Total Environ. 2021 Aug 20:783:147014.|Theranostics. 2021 Jan 1;11 (3) :1473-1492.|J Ethnopharmacol. 2025 Sep 9;355 (Pt A) :120587.

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