Sodium butyrate

Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity[1][2][3][4][5].

Product Specifications

CAS Number

[156-54-7]

Product Name Alternative

Butanoic acid (sodium) ; Butyric acid (sodium)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Autophagy; Endogenous Metabolite; HDAC

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.67

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CCCC(O[Na])=O

Molecular Formula

C4H7NaO2

Molecular Weight

110.09

Precautions

H315, H319, H335

References & Citations

[1]Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13 (2) :921-929|[2]Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14 (1) :34|[3]Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27|[4]Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32 (4) :224-230|[5]Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25.