Enalapril
Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].
Product Specifications
CAS Number
75847-73-3
Product Name Alternative
MK-421
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/enalapril.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H]1N(C([C@H](C)N[C@H](C(OCC)=O)CCC2=CC=CC=C2)=O)CCC1
Molecular Formula
C20H28N2O5
Molecular Weight
376.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22 (6) :698-705.|[2]Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer's disease. J Res Med Sci. 2013 Mar;18 (Suppl 1) :S1-5.|[3]Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14 (3) :1150-7.|[4]A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373 (1) :21-33.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Am J Transl Res. 2022 Jan 15;14 (1) :211-222.|Elife. 2025 Aug 28:14:RP104774.|Int J Clin Exp Pathol. 2020 May 1;13 (5) :827-836.|Nat Commun. 2023 May 2;14 (1) :2523.|Ren Fail. 2023;45 (2) :2253924.|bioRxiv. 2024 November 28.|bioRxiv. 2025 Jun 27:2025.06.24.660441.|Cardiooncology. 2025 Nov 13;11 (1) :106.|Environ Pollut. 2019 Apr:247:927-934.|Int J Nanomedicine. 2025 Oct 27:20:12993-13006.|Toxicol Lett. 2019 Jul:309:42-50.|Toxicology. 2023 Mar 1:486:153442.
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