Fenoprofen (Calcium)

Fenoprofen (LILLY-53858) Calcium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX) . Fenoprofen Calcium is a melanocortin receptors (MCRs) positive allosteric modulator (PAM) . Fenoprofen Calcium also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].

Product Specifications

CAS Number

[34597-40-5]

Product Name Alternative

LILLY-53858 (Calcium)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

COX; ERK; Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Fenoprofen-Calcium.html

Solubility

10 mM in DMSO

Smiles

CC(C(O)=O)C1=CC(OC2=CC=CC=C2)=CC=C1.[0.5Ca]

Molecular Formula

C15H14O3.1/2Ca

Molecular Weight

262.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yuan XC, et al. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1066-1074. |[2]Montero-Melendez T, et al. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74 (7) :1335-1345.