Pimobendan (hydrochloride)
Pimobendan hydrochloride (UD-CG115 hydrochloride) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
Product Specifications
CAS Number
77469-98-8
Product Name Alternative
UD-CG115 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335-H361
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Pimobendan-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1CC(C)C(C2=CC=C3N=C(C4=CC=C(OC)C=C4)NC3=C2)=NN1.Cl
Molecular Formula
C19H19ClN4O2
Molecular Weight
370.83
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Kajimoto K, et al. Contribution of phosphodiesterase isozymes to the regulation of the L-type calcium current in human cardiac myocytes. Br J Pharmacol. 1997 Aug;121 (8) :1549-56.|[2]Iwasaki A, et al. Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. J Am Coll Cardiol. 1999 Apr;33 (5) :1400-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PDE3
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