Pimobendan (hydrochloride)

Pimobendan hydrochloride (UD-CG115 hydrochloride) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.

Product Specifications

CAS Number

[77469-98-8]

Product Name Alternative

UD-CG115 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335-H361

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Pimobendan-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1CC(C)C(C2=CC=C3N=C(C4=CC=C(OC)C=C4)NC3=C2)=NN1.Cl

Molecular Formula

C19H19ClN4O2

Molecular Weight

370.83

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Kajimoto K, et al. Contribution of phosphodiesterase isozymes to the regulation of the L-type calcium current in human cardiac myocytes. Br J Pharmacol. 1997 Aug;121 (8) :1549-56.|[2]Iwasaki A, et al. Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. J Am Coll Cardiol. 1999 Apr;33 (5) :1400-7.