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Nafamostat (hydrochloride)

Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1) . Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall[1][2][3][4].

Product Specifications

CAS Number

80251-32-7

UNSPSC

12352005

Target

Apoptosis; Flavivirus; NF-κB; Ser/Thr Protease; TNF Receptor

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/nafamostat-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC(N)=N)C=C3.Cl.Cl

Molecular Formula

C19H19Cl2N5O2

Molecular Weight

420.29

References & Citations

[1]Uwagawa T, et al. Mechanisms of synthetic serine protease inhibitor (FUT‐175) ‐mediated cell death [J]. Cancer: Interdisciplinary International Journal of the American Cancer Society, 2007, 109 (10) : 2142-2153.|[2]Tajima H, et al. Enhanced invasiveness of pancreatic adenocarcinoma cells stably transfected with cationic trypsinogen cDNA [J]. International journal of cancer, 2001, 94 (5) : 699-704.|[3]Yan Y, et al. Nafamostat mesylate as a broad-spectrum candidate for the treatment of flavivirus infections by targeting envelope proteins [J]. Antiviral research, 2022, 202: 105325.|[4]Sawada M, et al. Prevention of neointimal formation by a serine protease inhibitor, FUT-175, after carotid balloon injury in rats [J]. Stroke, 1999, 30 (3) : 644-650.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

NF-κB

Citation 01

Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Adv Healthc Mater. 2025 Aug 1:e02156.|Antiviral Res. 2023 Jun:214:105606.|bioRxiv. 2024 October 09.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Cell Res. 2020 Mar;30 (3) :269-271.|Eur J Pharmacol. 2022 Mar 15:919:174795.|Eur J Pharmacol. 2023 Jan 5:938:175394.|Exp Mol Med. 2024 Dec;56 (12) :2631-2641.|Nat Chem Biol. 2022 Sep;18 (9) :963-971.|Nat Commun. 2024 Jun 27;15 (1) :5458.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Res Sq. 2025 Apr 07.|Viruses. 2022 Sep 12;14 (9) :2017.|Biomolecules. 2022 Jul 31;12 (8) :1063.|Cells. 2022 Jan 18;11 (3) :319.|Nucleic Acids Res. 2021 Jan 8;49 (D1) :D1113-D1121.|Patent. US20230210807A1.

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