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Nafamostat (hydrochloride)

Product Specifications

UNSPSC Description

Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall[1][2][3][4].

Target Antigen

Apoptosis; Flavivirus; NF-κB; Ser/Thr Protease; TNF Receptor

Type

Reference compound

Related Pathways

Anti-infection;Apoptosis;Metabolic Enzyme/Protease;NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/nafamostat-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC(N)=N)C=C3.Cl.Cl

Molecular Weight

420.29

References & Citations

[1]Uwagawa T, et al. Mechanisms of synthetic serine protease inhibitor (FUT‐175)‐mediated cell death [J]. Cancer: Interdisciplinary International Journal of the American Cancer Society, 2007, 109(10): 2142-2153.|[2]Tajima H, et al. Enhanced invasiveness of pancreatic adenocarcinoma cells stably transfected with cationic trypsinogen cDNA [J]. International journal of cancer, 2001, 94(5): 699-704.|[3]Yan Y, et al. Nafamostat mesylate as a broad-spectrum candidate for the treatment of flavivirus infections by targeting envelope proteins [J]. Antiviral research, 2022, 202: 105325.|[4]Sawada M, et al. Prevention of neointimal formation by a serine protease inhibitor, FUT-175, after carotid balloon injury in rats [J]. Stroke, 1999, 30(3): 644-650.Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Antiviral Res. 2023 Apr 17;105606.|bioRxiv. 2024 October 09.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|Cell Res. 2020 Mar;30(3):269-271.|Eur J Pharmacol. 2022 Feb 2;174795.|Eur J Pharmacol. 2022 Nov 17;175394.|Nat Chem Biol. 2022 Jun 8.|Nat Commun. 2024 Jun 27;15(1):5458.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Viruses. 2022, 14(9), 2017.|Biomolecules. 2022, 12(8), 1063.|Cells. 2022, 11(3), 319.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Patent. US20230210807A1.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-B0190B/Nafamostat-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-B0190B/

Clinical Information

Launched

CAS Number

80251-32-7

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