Deoxypodophyllotoxin
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis[1]. Deoxypodophyllotoxin induces cell autophagy and apoptosis[2]. Deoxypodophyllotoxin evokes increase of intracellular Ca2+ concentrations in DRG neurons[3].
Product Specifications
CAS Number
19186-35-7
UNSPSC
12352005
Hazard Statement
H310, H315, H319
Target
Apoptosis; Autophagy; Microtubule/Tubulin
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton
Applications
COVID-19-anti-virus
Field of Research
Infection; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/deoxypodophyllotoxin.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1[C@]2([H])[C@H](C3=CC(OC)=C(OC)C(OC)=C3)C4=CC(OCO5)=C5C=C4C[C@@]2([H])CO1
Molecular Formula
C22H22O7
Molecular Weight
398.41
Precautions
H310, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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