Felbamate (hydrate)

Felbamate hydrate (W-554 hydrate) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .

Product Specifications

CAS Number

[1177501-39-1]

Product Name Alternative

W-554 (hydrate) ; ADD-03055 (hydrate)

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/felbamate-hydrate.html

Solubility

10 mM in DMSO

Smiles

NC(OCC(C1=CC=CC=C1)COC(N)=O)=O.O

Molecular Formula

C11H16N2O5

Molecular Weight

256.26

References & Citations

[1]Kuo CC, et al. Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channels. Mol Pharmacol. 2004 Feb;65 (2) :370-80.|[2]Harty TP, et al. Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39 (1) :47-55.