Pizotifen (malate)
Pizotifen malate (Pizotyline malate) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
Product Specifications
CAS Number
5189-11-7
Product Name Alternative
Pizotyline (malate) ; BC-105 (malate)
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pizotifen-malate.html
Purity
99.04
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)C(O)CC(O)=O.CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=C\2C=CS4
Molecular Formula
C23H27NO5S
Molecular Weight
429.53
Precautions
H302, H312, H332
References & Citations
[1]Mylecharane EJ, et al. 5-HT2 receptor antagonists and migraine therapy. J Neurol. 1991;238 Suppl 1:S45-52.|[2]Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9 (1) :e87026.|[3]Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. Agents Actions. 1988 Apr;23 (3-4) :376-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; α-1 microglobulin
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