Pizotifen (malate)

Pizotifen malate (Pizotyline malate) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.

Product Specifications

CAS Number

[5189-11-7]

Product Name Alternative

Pizotyline (malate) ; BC-105 (malate)

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pizotifen-malate.html

Purity

99.04

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)C(O)CC(O)=O.CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=C\2C=CS4

Molecular Formula

C23H27NO5S

Molecular Weight

429.53

Precautions

H302, H312, H332

References & Citations

[1]Mylecharane EJ, et al. 5-HT2 receptor antagonists and migraine therapy. J Neurol. 1991;238 Suppl 1:S45-52.|[2]Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9 (1) :e87026.|[3]Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. Agents Actions. 1988 Apr;23 (3-4) :376-8.