Naloxegol
Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation[1][2].
Product Specifications
CAS Number
854601-70-0
Product Name Alternative
NKTR-118; AZ-13337019
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Naloxegol.html
Solubility
10 mM in DMSO
Smiles
O[C@@]1(CC[C@H](OCCOCCOCCOCCOCCOCCOCCOC)[C@]2([H])OC3=C4O)[C@]52C3=C(C=C4)C[C@@]1([H])N(CC=C)CC5
Molecular Formula
C34H53NO11
Molecular Weight
651.78
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Front Immunol. 2021 Jul 7:12:692286.|Eur J Pharmacol. 2021 Jul 15:903:174132.
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