7-xylosyltaxol

7-xylosyltaxol (Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules. IC50 Value: Target: Microtubule/Tubulin Paclitaxel is a compound extracted from the Pacific yew tree with antineoplastic activity. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2) . Paclitaxel inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Paclitaxel induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

Product Specifications

CAS Number

[90332-66-4]

Product Name Alternative

7-Xylosylpaclitaxel; Taxol-7-xyloside

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Microtubule/Tubulin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-xylosyltaxol.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1)N[C@@H](C2=CC=CC=C2)[C@@H](O)C(O[C@@H]3C(C)=C([C@@H](OC(C)=O)C([C@@]4(C)[C@]([C@](OC(C)=O)(CO5)[C@@]5([H])C[C@@H]4O[C@@]6([H])[C@H](O)[C@@H](O)[C@H](O)CO6)([H])[C@@H]7OC(C8=CC=CC=C8)=O)=O)C(C)(C)[C@@]7(O)C3)=O

Molecular Formula

C52H59NO18

Molecular Weight

986.02

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23 (10) :2641-7.|[2]Chao Z, Tan M, Paudel MK, et al. Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel. J Nat Med. 2012 Sep 25.|[3]Park SJ, Wu CH, Gordon JD, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279 (49) :51057-67. Epub 2004 Sep 27.|[4]Rao S, He L, Chakravarty S, et al. Characterization of the Taxol binding site on the microtubule. Identification of Arg (282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J Biol Chem. 1999 Dec 31;274 (53) :37990-4.|[5]Paclitaxel