Zaurategrast ethyl ester sulfate

Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2].

Product Specifications

CAS Number

[1214261-78-5]

Product Name Alternative

CDP323 sulfate; UCB1184197 sulfate

UNSPSC

12352005

Hazard Statement

H318

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Zaurategrast_ethyl_ester_sulfate.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC)[C@H](CC1=CC=C(NC2=NC=CC3=C2C=NC=C3)C=C1)NC4=C(Br)C(C45CCCCC5)=O.O=S(O)(O)=O

Molecular Formula

C28H29BrN4O3.1/2H2O4S

Molecular Weight

647.54

Precautions

P280-P305+P351+P338

References & Citations

[1]Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43 (9) :1381-91.|[2]Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12 (13-14) :569-76.