Zaurategrast ethyl ester sulfate
Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders[2].
Product Specifications
CAS Number
1214261-78-5
Product Name Alternative
CDP323 sulfate; UCB1184197 sulfate
UNSPSC
12352005
Hazard Statement
H318
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Zaurategrast_ethyl_ester_sulfate.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC)[C@H](CC1=CC=C(NC2=NC=CC3=C2C=NC=C3)C=C1)NC4=C(Br)C(C45CCCCC5)=O.O=S(O)(O)=O
Molecular Formula
C28H29BrN4O3.1/2H2O4S
Molecular Weight
647.54
Precautions
P280-P305+P351+P338
References & Citations
[1]Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43 (9) :1381-91.|[2]Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12 (13-14) :569-76.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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