Tenofovir alafenamide hemifumarate

Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

Product Specifications

CAS Number

[1392275-56-7]

Product Name Alternative

GS-7340 (hemifumarate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/GS-7340-hemifumarate.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)/C=C/C(O)=O.NC1=NC=NC2=C1N=CN2C[C@@H](C)OC[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O.[0.5]

Molecular Formula

C21H29N6O5P.1/2 C4H4O4

Molecular Weight

534.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Birkus G, et al. Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors. Antimicrob Agents Chemother. 2015 Oct 26;60 (1) :316-22.|[2]Callebaut C, et al. In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate. Antimicrob Agents Chemother. 2015 Oct;59 (10) :5909-16.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

HIV-1; HIV-2

Citation 01

Preprints. 2024 Apr 19.|ACS Infect Dis. 2025 Oct 30.|Antimicrob Agents Chemother. 2019 Mar 27;63 (4) . pii: e02143-18.|Antimicrob Agents Chemother. 2019 Mar 27;63 (4) :e02143-18.|J Antimicrob Chemother. 2017 Jun 1;72 (6) :1731-1740.|J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Oct 1.|J Gastroenterol. 2020 Apr;55 (4) :441-452|J Med Chem. 2024 May 9;67 (9) :7470-7486.|Pharmaceuticals (Basel) . 2025 Oct 16;18 (10) :1560.|Pharmaceutics. 2021 Oct 11;13 (10) :1656.|Research Square Print. 2023 Mar 20.