Bay 65-1942 (free base)
Bay 65-1942 free base is an ATP-competitive and selective IKKβ inhibitor.
Product Specifications
CAS Number
600734-02-9
UNSPSC
12352005
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bay-65-1942-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C1OCC2=C([C@H]3CNCCC3)C=C(C4=C(O)C=CC=C4OCC5CC5)N=C2N1
Molecular Formula
C22H25N3O4
Molecular Weight
395.45
References & Citations
[1]Moss NC, et al. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Oct;293 (4) :H2248-53.|[2]Cooper MJ, et al. Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One. 2013 Jun 24;8 (6) :e66755.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β
Citation 01
Oncogene. 2016 Aug 4;35 (31) :4036-47.|Cell Mol Immunol. 2023 Apr;20 (4) :351-364.|FASEB Bioadv. 2025 Oct 23;7 (10) :e70050.|Int Immunopharmacol. 2020 Nov;88:107020.
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