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Mavorixafor

Mavorixafor (AMD-070) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. Mavorixafor can be used for the study of WHIM syndrome[1].

Product Specifications

CAS Number

558447-26-0

Product Name Alternative

AMD-070; AMD-11070

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CXCR; HIV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/amd-070.html

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NCCCCN(CC1=NC2=C(N1)C=CC=C2)[C@@H]3C4=C(CCC3)C=CC=N4

Molecular Formula

C21H27N5

Molecular Weight

349.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53 (8) :3376-88.|[2]Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. Oncol Rep. 2018 Jul;40 (1) :303-308.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

CXCR4; HIV-1

Citation 01

Biosci Rep. 2023 Dec 22;43 (12) :BSR20230981.|Br J Haematol. 2023 May;201 (3) :459-469.|Cell Mol Life Sci. 2024 Mar 13;81 (1) :132.|Patent. US20220273751A1.|PLoS One. 2016 Mar 21;11 (3) :e0151765.|Am J Physiol Cell Physiol. 2025 Apr 1;328 (4) :C1260-C1278.|Oncol Rep. 2022 Apr;47 (4) :68.|Proc Natl Acad Sci U S A. 2025 Mar 18;122 (11) :e2425795122.

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