Mono- (2-ethylhexyl) phthalate-d4

Mono- (2-ethylhexyl) phthalate-d4 is a deuterium labeled Mono- (2-ethylhexyl) phthalate (HY-W018392) . Mono- (2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP) . Mono- (2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) [1][2].

Product Specifications

CAS Number

[1276197-22-8]

Product Name Alternative

MEHP-d4; Phthalic acid mono-2-ethylhexyl ester-d4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

CCCCC(CC)COC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])C(O)=O)=O

Molecular Formula

C16H18D4O4

Molecular Weight

282.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Bai J, et al. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environ Toxicol Pharmacol. 2019 Jul;69:104-111.|[3]Tomita I, et al. Fetotoxic effects of mono-2-ethylhexyl phthalate (MEHP) in mice. Environ Health Perspect. 1986 Mar;65:249-54.