Aminaftone

Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene.

Product Specifications

CAS Number

[14748-94-8]

Product Name Alternative

Aminaftone; Aminaphthone

UNSPSC

12352005

Hazard Statement

H400

Target

Endothelin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Aminaftone.html

Solubility

10 mM in DMSO

Smiles

OC1=C2C=CC=CC2=C(O)C(C)=C1OC(C3=CC=C(N)C=C3)=O

Molecular Formula

C18H15NO4

Molecular Weight

309.32

Precautions

P273-P391-P501

References & Citations

[1]Scorza R, et al. Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 production in ECV304 Cells: an in vitro Study. Drugs R D. 2008;9 (4) :251-7.|[2]Zambelli V, et al. Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension. Eur J Pharmacol. 2011 Sep 30;667 (1-3) :287-91.