Aminaftone
Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene.
Product Specifications
CAS Number
14748-94-8
Product Name Alternative
Aminaftone; Aminaphthone
UNSPSC
12352005
Hazard Statement
H400
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Aminaftone.html
Solubility
10 mM in DMSO
Smiles
OC1=C2C=CC=CC2=C(O)C(C)=C1OC(C3=CC=C(N)C=C3)=O
Molecular Formula
C18H15NO4
Molecular Weight
309.32
Precautions
P273-P391-P501
References & Citations
[1]Scorza R, et al. Aminaftone, a derivative of 4-aminobenzoic acid, downregulates endothelin-1 production in ECV304 Cells: an in vitro Study. Drugs R D. 2008;9 (4) :251-7.|[2]Zambelli V, et al. Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension. Eur J Pharmacol. 2011 Sep 30;667 (1-3) :287-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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