Tilapertin
Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1) .
Product Specifications
CAS Number
[1000690-85-6]
Product Name Alternative
AMG747
UNSPSC
12352005
Target
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tilapertin.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CN1CCN([C@H](C2=CC=CC=C2)C3=CC=CC(C(F)(F)F)=C3)CC1
Molecular Formula
C20H21F3N2O2
Molecular Weight
378.39
References & Citations
[1]Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
GlyT1
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