Tilapertin

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1) .

Product Specifications

CAS Number

[1000690-85-6]

Product Name Alternative

AMG747

UNSPSC

12352005

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tilapertin.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CN1CCN([C@H](C2=CC=CC=C2)C3=CC=CC(C(F)(F)F)=C3)CC1

Molecular Formula

C20H21F3N2O2

Molecular Weight

378.39

References & Citations

[1]Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

GlyT1

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