Pancopride

Pancopride is a new potent and selective 5-HT3 receptor antagonist.

Product Specifications

CAS Number

[121650-80-4]

Product Name Alternative

LAS 30451

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Pancopride.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1CN2CCC1CC2)C3=CC(Cl)=C(N)C=C3OCC4CC4

Molecular Formula

C18H24ClN3O2

Molecular Weight

349.86

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Fernández AG, et al. Pancopride, a potent and long-acting 5-HT3 receptor antagonist, is orally effective against anticancer drug-evoked emesis. Eur J Pharmacol. 1992 Nov 10;222 (2-3) :257-64.|[2]Grande L, et al. Lack of effect of a 5-HT3 antagonist, pancopride, on lower oesophageal sphincter pressure in volunteers. Br J Clin Pharmacol. 1995 Oct;40 (4) :401-3.