U-101017
U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects.
Product Specifications
CAS Number
[170568-47-5]
Product Name Alternative
PNU 101017
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/U-101017.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2N(C=N1)C3=C(C=C(Cl)C=C3)C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)=C2)OC(C)(C)C
Molecular Formula
C23H27ClN4O3
Molecular Weight
442.94
References & Citations
[1]Hall ED, et al. Comparative neuroprotective properties of the benzodiazepine receptor full agonist diazepam and the partial agonist PNU-101017 in the gerbil forebrain ischemia model. Brain Res. 1998 Jul 6;798 (1-2) :325-9.|[2]Sethy VH, et al. The novel anxiolytic U-101017: in vitro and ex vivo binding profile and effect on cerebellar cGMP. Pharmacol Biochem Behav. 1997 Oct;58 (2) :609-13.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19250/U-101017-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19250/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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