U-101017

U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects.

Product Specifications

CAS Number

[170568-47-5]

Product Name Alternative

PNU 101017

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/U-101017.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2N(C=N1)C3=C(C=C(Cl)C=C3)C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)=C2)OC(C)(C)C

Molecular Formula

C23H27ClN4O3

Molecular Weight

442.94

References & Citations

[1]Hall ED, et al. Comparative neuroprotective properties of the benzodiazepine receptor full agonist diazepam and the partial agonist PNU-101017 in the gerbil forebrain ischemia model. Brain Res. 1998 Jul 6;798 (1-2) :325-9.|[2]Sethy VH, et al. The novel anxiolytic U-101017: in vitro and ex vivo binding profile and effect on cerebellar cGMP. Pharmacol Biochem Behav. 1997 Oct;58 (2) :609-13.