CMI-392

CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively.

Product Specifications

CAS Number

[193739-23-0]

Product Name Alternative

LDP-392

UNSPSC

12352005

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/CMI-392.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC([C@H]2O[C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC2)=CC(OC)=C1OCCSC4=CC=C(Cl)C=C4)N(O)C

Molecular Formula

C31H37ClN2O8S

Molecular Weight

633.15

References & Citations

[1]Cai X, et al. (+/-) -trans-2-[3-methoxy-4- (4-chlorophenylthioethoxy) -5- (N-methyl-N- hydroxyureidyl) methylphenyl]-5- (3,4, 5-trimethoxyphenyl) tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist. J Med Chem. 1998 May 21;41 (11) :1970-9.