CMI-392
CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively.
Product Specifications
CAS Number
193739-23-0
Product Name Alternative
LDP-392
UNSPSC
12352005
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/CMI-392.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC([C@H]2O[C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC2)=CC(OC)=C1OCCSC4=CC=C(Cl)C=C4)N(O)C
Molecular Formula
C31H37ClN2O8S
Molecular Weight
633.15
References & Citations
[1]Cai X, et al. (+/-) -trans-2-[3-methoxy-4- (4-chlorophenylthioethoxy) -5- (N-methyl-N- hydroxyureidyl) methylphenyl]-5- (3,4, 5-trimethoxyphenyl) tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist. J Med Chem. 1998 May 21;41 (11) :1970-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-LOX
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