RG-12915

RG-12915 is a selective 5-HT3 antagonist, with IC50 value of 0.16 nM.

Product Specifications

CAS Number

[136174-04-4]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RG-12915.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C2O[C@](CCCC3)([H])[C@]3([H])C2=CC(Cl)=C1)N[C@@H]4CN5CCC4CC5

Molecular Formula

C20H25ClN2O2

Molecular Weight

360.88

References & Citations

[1]Fitzpatrick LR, et al. RG 12915: a potent 5-hydroxytryptamine-3 antagonist that is an orally effective inhibitor of cytotoxic drug-induced emesis in the ferret and dog. J Pharmacol Exp Ther. 1990 Aug;254 (2) :450-5.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

Lactoferrin

Available Sizes

Curated Selection

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