RG-12915
RG-12915 is a selective 5-HT3 antagonist, with IC50 value of 0.16 nM.
Product Specifications
CAS Number
[136174-04-4]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RG-12915.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C2O[C@](CCCC3)([H])[C@]3([H])C2=CC(Cl)=C1)N[C@@H]4CN5CCC4CC5
Molecular Formula
C20H25ClN2O2
Molecular Weight
360.88
References & Citations
[1]Fitzpatrick LR, et al. RG 12915: a potent 5-hydroxytryptamine-3 antagonist that is an orally effective inhibitor of cytotoxic drug-induced emesis in the ferret and dog. J Pharmacol Exp Ther. 1990 Aug;254 (2) :450-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Lactoferrin
Available Sizes
Curated Selection
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