CV-159
CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.
Product Specifications
CAS Number
86384-98-7
UNSPSC
12352005
Target
Calmodulin
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/CV-159.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)NC(C)=C(C(OCCCCCCOC2=NNC(C3=CC=CC=C3)=C2)=O)C1C4=CC=CC([N+]([O-])=O)=C4)OC
Molecular Formula
C31H34N4O7
Molecular Weight
574.62
References & Citations
[1]Usui T, et al. Mechanisms underlying the anti-inflammatory effects of the Ca2+/calmodulin antagonist CV-159 in cultured vascular smooth muscle cells. J Pharmacol Sci. 2010;113 (3) :214-23. Epub 2010 Jun 16.|[2]Usui T, et al. CV-159, a unique dihydropyridine derivative, prevents TNF-induced inflammatory responses in human umbilical vein endothelial cells. J Pharmacol Sci. 2010;113 (2) :182-91. Epub 2010 May 19.|[3]Miyazaki H, et al. Neuroprotective effects of a dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarbox ylic acid methyl 6- (5-phenyl-3-pyrazolyloxy) hexyl ester (CV-159), on rat ischemic brain injury. Life Sci. 1999;64 (10) :869-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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