Polyclonal ETO/RUNX1T1 Antibody

<strong>Polyclonal ETO/RUNX1T1 Antibody</strong>_x000D_ <strong>Catalog number:</strong> B2016957_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µL_x000D_ <strong>Molecular Weight or Concentration:</strong> 68 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20¬∞C_x000D_ <strong>Keywords:</strong> CDR, MTG8, AML1T1, ZMYND2, CBFA2T1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Le XF, Claxton D, Kornblau S, Fan YH, Mu ZM, Chang KS. Characterization of the ETO and AML1-ETO proteins involved in 8;21 translocation in acute myelogenous leukemia Eur J Haematol. 1998 Apr;60(4):217-25._x000D_ 2: Lindberg SR, Olsson A, Persson AM, Olsson I. Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins Eur J Haematol. 2003 Dec;71(6):439-47._x000D_ 3: Barbetti V, Tusa I, Cipolleschi MG, Rovida E, Dello Sbarba P. AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia Cell Death Dis. 2013 Mar 14;4(3):e536._x000D_ 4: Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA. ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease Blood. 1996 Sep 1;88(5):1813-23._x000D_ 5: Esposito MT, Zhao L, Fung TK, Rane JK, Wilson A, Martin N, Gil J, Leung AY, Ashworth A, So CW. Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors Nat Med. 2015 Dec;21(12):1481-90._x000D_ 6: Simkins SG, Knapp SL, Brough GH, Lenz KL, Barley-Maloney L, Baker JP, Dekking L, Wai H, Dixon EP. Generation of monoclonal antibodies to the AML1-ETO fusion protein: strategies for overcoming high homology Hybridoma (Larchmt). 2011 Oct;30(5):433-43._x000D_ 7: Ugarte GD, Vargas MF, Medina MA, Le√≥n P, Necu√±ir D, Elorza AA, Guti√©rrez SE, Moon RT, Loyola A, De Ferrari GV. Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells Blood. 2015 Oct 8;126(15):1785-9._x000D_ 8: Ajore R, Kumar P, Dhanda RS, Gullberg U, Olsson I. The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells BMC Mol Biol. 2012 Mar 23;13:11._x000D_ 9: Stuardo M, Nicovani S, Javed A, Gutierrez S. Breakpoint regions of ETO gene involved in (8; 21) leukemic translocations are enriched in acetylated histone H3 J Cell Biochem. 2013 Nov;114(11):2569-76._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/9473235">10: Tanaka K, Tanaka T, Kurokawa M, Imai Y, Ogawa S, Mitani K, Yazaki Y, Hirai H. The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2beta(CBFbeta) in the nucleus more efficiently than wild-type AML1 Blood. 1998 Mar 1;91(5):1688-99.</a>_x000D_ _x000D_ <strong>Products Related to Polyclonal ETO/RUNX1T1 Antibody can be found at</strong> <a href="https://moleculardepot.com/product-category/Antibodies/"> Antibodies</a>