PFI-2
PFI-2 ((R) -PFI-2 hydrochloride) hydrochloride, a chemical probe, is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R) -PFI-2 shows high inhibiting activity with IC50 value of 2.0 nM and (S) -PFI-2 shows inhibiting activity with IC50 value of 1.0 μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis[1][2].
Product Specifications
CAS Number
1627676-59-8
Product Name Alternative
(R) -PFI-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PFI-2.html
Purity
99.68
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O
Molecular Formula
C23H25F4N3O3S
Molecular Weight
499.52
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SETD7/KMT7
Citation 01
Available Sizes
Frequently Asked Questions
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