KNK437
Product Specifications
UNSPSC Description
KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40.
Target Antigen
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KNK437.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=CN1C(/C(CC1)=C/C2=CC=C(OCO3)C3=C2)=O
Molecular Weight
245.23
References & Citations
[1]Yokota S, et al. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res. 2000 Jun 1;60(11):2942-8.|[2]Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9.|[3]Matsuda K, et al. Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells. Int J Hyperthermia. 2006 Dec;22(8):729-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100110/KNK437-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100110/KNK437-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
218924-25-5
Available Sizes
Curated Selection
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