Tropicamide

Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. When used as an eye drop, Tropicamide causes short-term mydriasis (pupil dilation) and cycloplegia. Tropicamide can be used in the research of neurological diseases, such as epilepsy[1][2][3][4].

Product Specifications

CAS Number

[1508-75-4]

Product Name Alternative

Ro 1-7683

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tropicamide.html

Concentration

10mM

Purity

99.22

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N(CC)CC1=CC=NC=C1)C(C2=CC=CC=C2)CO

Molecular Formula

C17H20N2O2

Molecular Weight

284.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38 (6) : p. 805-15.|[2]Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110 (4) : p. 1413-20.|[3]Veeraragavan S, et al. The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide. Behav Neurosci. 2011 Oct;125 (5) :783-90.|[4]Betz AJ, et al. The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. Psychopharmacology (Berl) . 2007 Oct;194 (3) :347-59.