Spebrutinib (besylate)
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50Kinact/Ki=7.69x104 M-1s-1s) in biochemical assays.
Product Specifications
CAS Number
1360053-81-1
Product Name Alternative
AVL-292 (benzenesulfonate) ; CC-292 (besylate)
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AVL-292-benzenesulfonate.html
Solubility
10 mM in DMSO
Smiles
COCCOC1=CC=C(NC2=NC=C(F)C(NC3=CC=CC(NC(C=C)=O)=C3)=N2)C=C1.O=S(C4=CC=CC=C4)(O)=O
Molecular Formula
C28H28FN5O6S
Molecular Weight
581.62
References & Citations
[1]Evans EK, et al. Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug;346 (2) :219-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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