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Piperazine (citrate)

Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist[1]. Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities[2].

Product Specifications

CAS Number

144-29-6

Product Name Alternative

1,4-Diazacyclohexane (citrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Piperazine-citrate.html

Purity

98.0

Solubility

DMSO : 2.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(CC(C(O)=O)(O)CC(O)=O)O.O=C(CC(C(O)=O)(O)CC(O)=O)O.N1CCNCC1.N2CCNCC2.N3CCNCC3

Molecular Formula

C6H8O7.3/2C4H10N2

Molecular Weight

321.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Lovell RA. Ivermectin and piperazine toxicoses in dogs and cats. Vet Clin North Am Small Anim Pract. 1990;20 (2) :453-468. |[2]Girase PS, et al. An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review. Eur J Med Chem. 2021;210:112967. |[3]Jain A, et al. Piperazine: A Promising Scaffold with Analgesic and Anti-inflammatory Potential. Drug Res (Stuttg) . 2021;71 (2) :62-72. |[4]Kumar RR, et al. Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure-Activity Relationships. ChemMedChem. 2021;16 (12) :1878-1901.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Frequently Asked Questions

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