Prostaglandin D1-d4
Prostaglandin D1-d4 (PGD1-d4) is deuterium labeled Prostaglandin D1. Prostaglandin D1 is a prostanoid which causes contractile and relaxant on isolated human pial arteries, it is also an inhibitor of ADP-induced platelet aggregation with an IC50 value of 320 ng/ml. Prostaglandin D1 can be used for metabolic research[1][2].
Product Specifications
Product Name Alternative
PGD1-d4
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease
Smiles
CCCCC[C@@H](/C=C/[C@H]1C(C[C@@H]([C@@H]1CCCC(C([2H])(CC(O)=O)[2H])([2H])[2H])O)=O)O
Molecular Formula
C20H30D4O5
Molecular Weight
358.51
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Bundy GL, et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem. 1983 Jun;26 (6) :790-9.|[3]Uski TK, et al. Characterization of the prostanoid receptors and of the contractile effects of prostaglandin F2 alpha in human pial arteries. Acta Physiol Scand. 1984 Aug;121 (4) :369-78.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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