Levalbuterol (tartrate)

Levosalbutamol tartrate (levalbuterol) is the R-enantiomer of the short-acting β2-adrenergic receptor agonist salbutamol. IC50 Value: Target: β2-adrenergic receptor Levosalbutamol and salbutamol produced significantly better bronchodilator responses than placebo. Both the drugs showed equivalent time-dependent bronchodilator responses as measured by area under curve for percent change in FEV (1) and FVC over 6h. The time to onset of action, mean maximum bronchodilator response and duration of bronchodilator response were similar between levosalbutamol and salbutamol [1].

Product Specifications

CAS Number

[661464-94-4]

Product Name Alternative

Levosalbutamol tartrate

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/levalbuterol-tartrate.html

Solubility

10 mM in DMSO

Smiles

OC1=C(CO)C=C([C@@H](O)CNC(C)(C)C)C=C1.OC2=C(CO)C=C([C@@H](O)CNC(C)(C)C)C=C2.OC([C@H](O)[C@@H](O)C(O)=O)=O

Molecular Formula

C30H48N2O12

Molecular Weight

628.71

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Jantikar A, et al. Comparison of bronchodilator responses of levosalbutamol and salbutamol given via a pressurized metered dose inhaler: a randomized, double blind, single-dose, crossover study. Respir Med. 2007 Apr;101 (4) :845-9.