(R) -Baclofen (hydrochloride)

(R) -Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist[1][2].

Product Specifications

CAS Number

[63701-55-3]

Product Name Alternative

Arbaclofen (hydrochloride) ; STX 209 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_r_-baclofen-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C([C@](CC(O)=O)([H])CN)C=C1.Cl

Molecular Formula

C10H13Cl2NO2

Molecular Weight

250.12

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Mezler M, et al. Cloning and functional expression of GABA (B) receptors from Drosophila. Eur J Neurosci. 2001 Feb;13 (3) :477-86.|[2]Dzitoyeva S, et al. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003 Apr 29;100 (9) :5485-90. Epub 2003 Apr 11.|[3]Henderson C, et al. Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. Sci Transl Med. 2012 Sep 19;4 (152) :152ra128.