Eravacycline
Product Specifications
UNSPSC Description
Eravacycline is a potent and broad-spectrum antibacterial agent.
Target Antigen
Antibiotic; Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Eravacycline.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(C(O)=C1C2=O)=CC(F)=C1C[C@@]3([H])C[C@@]4([H])[C@H](N(C)C)C(O)=C(C(N)=O)C([C@@]4(O)C(O)=C32)=O)CN5CCCC5
Molecular Weight
558.56
References & Citations
[1]Seifert H, et al. In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii. Int J Antimicrob Agents. 2017 Jul 10.|[2]Zhao M, et al. In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model. Antimicrob Agents Chemother. 2017 Jun 27;61(7).|[3]Xiao XY, et al. Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent. J Med Chem. 2012 Jan 26;55(2):597-605.|[4]Sutcliffe JA, et al. Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens. Antimicrob Agents Chemother. 2013 Nov;57(11):5548-58.|[5]Grossman TH, et al. Eravacycline (TP-434) is efficacious in animal models of infection. Antimicrob Agents Chemother. 2015 May;59(5):2567-71.Ann Lab Med. 2021 May 1;41(3):293-301.|Antibiotics (Basel). 2022, 11(10), 1298.|Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00470-19.|Antimicrob Agents Chemother. 2021 May 18;65(6):e00203-21.|Antimicrob Agents Chemother. 2024 Jan 30:e0112023.|Clin Exp Pharmacol Physiol. 2023 Apr 22.|Diagn Micr Infec Dis. 2020 Nov;98(3):115129.|Infect Drug Resist. 2023 Apr 17.|Infect Drug Resist. 2023 Sep 7.|J Antibiot (Tokyo). 2019 Aug;72(8):600-604. |J Antibiot (Tokyo). 2022 Jul 27.|J Antimicrob Chemother. 2021 May 6;dkab141.|J Clin Microbiol. 2020 Jan 28;58(2):e01603-19.|Microbiol Spectr. 2022 Dec 8;e0323822.|Microbiol Spectr. 2023 May 4;e0071823.|Nat Microbiol. 2023 Mar;8(3):410-423.|Nat Struct Mol Biol. 2023 Aug 7.|Virulence. 2022 Dec;13(1):77-88.|Biomaterials. 2024 Sep 11:314:122815.|J Antimicrob Chemother. 2021 Feb 11;76(3):653-658.|Mbio. 2021 May 28;e0103121.|Microb Pathog. 2020 Dec;149:104502.|Pharmaceutics. 2021, 13(12), 2085.|Research Square Preprint. 2022 Feb.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16980/Eravacycline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16980/
Clinical Information
Launched
CAS Number
1207283-85-9
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