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Crocetin (Standard)

Crocetin (Standard) (TransCrocetin (Standard) ) is an aglycone of crocin. Crocetin (Standard) is orally active and brain-penetrant. Crocetin (Standard) shows strong NMDA receptor affinity and channel opening activity. Crocetin (Standard) can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin (Standard) can inhibit apoptosis and activation of MAPK. Crocetin (Standard) can delay delays brain and body aging. Crocetin (Standard) can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia[1][2][3][4].

Product Specifications

CAS Number

27876-94-4

Product Name Alternative

Transcrocetin (Standard) ; trans-Crocetin (Standard)

UNSPSC

12352211

Target

Apoptosis; COX; iGluR; p38 MAPK; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/crocetin-standard.html

Purity

96.79

Smiles

O=C(O)/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O)=O

Molecular Formula

C20H24O4

Molecular Weight

328.40

References & Citations

[1]Chen B, et al. Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells. Biomed Res Int. 2015;2015:829513.|[2]Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice. Eur J Pharmacol. 2013 Mar 5;703 (1-3) :1-10.|[3]Choudhary S, et al. Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice. ACS Pharmacol Transl Sci. 2024 Sep 11;7 (10) :3017-3033.|[4]Lautenschläger M, et al. Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22 (1) :36-44.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Isoform

COX-2; NMDA Receptor

Available Sizes

Frequently Asked Questions

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